The MotherCare project was one of the earliest global efforts made to tackle maternal mortality. MotherCare was the global maternal health project developed by the United States Agency for International Development (USAID) with the goal of improving pregnancy outcomes for mothers and their newborns. MotherCare Nigeria was a 19-month offshoot of the global programme. (March 1992 to September 1993).

The seminal 1994 research examined factors that contribute to maternal mortality. Factors include: 1. delay the decision to seek care; 2. delay arrival at a health facility; and 3. delay the provision of adequate care. The study indicated that while distance and cost are major obstacles in the decision to seek care, the relationships are not simple. There is evidence that people often consider the quality of care more important than cost. These three factors--distance, cost and quality--alone do not give a full understanding of decision-making process. Their salience as obstacles is ultimately defined by illness-related factors, such as severity. Differential use of health services is also shaped by such variables as gender and socioeconomic status. Patients who make a timely decision to seek care can still experience delay, because the accessibility of health services is an acute problem in the developing world.

Situation analyses were conducted by 11 multidisciplinary teams in the West African Prevention of Maternal Mortality (PMM) Network, with technical assistance from Columbia University's Center for Population and Family Health. The research summarizes the results from eleven situation analyses conducted by the Prevention of Maternal Mortality (PMM) Network and concentrates on examining hospital utilization patterns and other health system factors contributing to deaths in childbirth.

Child Spacing and Family Health was a pilot project planned at the 1994 Rotary International Assembly. The project was started in two communities in Kaduna and gave training to nurses, doctors, midwives, and village health workers. It supplied poor hospitals with essential medical equipment, and it educated people about the benefits of family planning and made contraception more widely available. RFPD also set up contraception distribution cupboards in 21 hospitals. According to findings of an independent evaluation carried out by the German Foundation for World Population, Deutsche Stiftung Weltbevoelkerung (DSW), contraception use soared from 3 to 27 percent in participating hospitals during the five years of the project.

The Maternal and Neonatal Tetanus Elimination Initiative was launched by UNICEF, WHO and UNFPA in 1999, revitalizing the goal of MNTE as a public health problem. The definition of Neonatal Tetanus (NT) elimination as a public health problem is having less than one NT case per 1000 live births in every district per year. Maternal tetanus is assumed to be eliminated once NT elimination has been achieved. According to WHO, countries are encouraged to develop an MNT plan of action (PoA), detailing how they would proceed to eliminate MNT through the implementation of the recommended strategies. The PoA is then submitted to UNICEF or other partners for financial and technical support. One major component of most plans is the implementation of TT Supplementary Immunization Activities (TT-SIAs) in high risk districts (HRD). TT SIAs are then implemented as per the country's capacity and available resources. In 2014, 2015, 2016, 2017, 2018 and 2019, Nigeria implemented TT SIAs.